Hey,
Your setup sounds pretty solid for a versatile home studio! The Focusrite Scarlett 2i2 is a grat choice; it's renowned for its reliability and excellent audio quality, making it perfect for both beginners and seasoned producers. The Shure SM7B will serve you well, especially for vocal recordings—it's a staple in many professional studios due to its warmth and smooth sound.
The Yamaha HS5 monitors are a fantastic option as they offer very flat response, which is crucial for accurate mixing. However, depending on the size of your room, you might want to consider if the 5-inch model is the best fit or if you'd benefit from stepping up to the HS7s for more low-end representation.
For the MIDI controller, the NI Komplete Kontrol S49 MK2 is indeed top-tier with its deep integration capabilities. It should produce navigating plugins and virtual instruments a breeze.
Lastly, the Audio-Technica ATH-M50x headphones are definitely a popular choice. They offer clear, detailed sound and good isolation. Great for checking your mixes without disturbing others.
Regarding cable management, I highly recommend getting some cable sleeves or ties to keep everything organized and avoid any potential cable damage or safety hazards. For acoustic treatment, start with bass traps in the corners and some acoustic panels at first reflection points. This initial setup can significantly improve your listening environment which will be reflected in your productions.
It seems like you’ve done your homework well! Let us know how it all comes together once you've got everything set up.
Cheers!